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KMID : 0359920100290060834
Korean Journal of Nephrology
2010 Volume.29 No. 6 p.834 ~ p.838
Delayed Recovery of Sedation by Continuous Midazolam Infusion in an ESRD Patient on Peritoneal Dialysis: A Case Report


Kim So-Young
Choi Hae-Jin
Park Hyun-Sik
Yun Seon-Ung
Bae Byeong-Joo
Park Jung-Hwan
Lee Jong-Ho
Jo Young-Il
Abstract
Midazolam, a benzodiazepine derivatives, is widely used in intensive care unit for sedation of patients who require mechanical ventilation. Although midazolam has a short acting time, it might cause a prolonged sedation, especially in patients with renal failure. We report the case of a 76-year-old man who received peritoneal dialysis and showed prolonged sedation after stopping continuous infusion of midazolam. The patient who has received maintenance hemodialysis for five months admitted in intensive care unit to manage pneumonia and severe congestive heart failure. In ICU, hemodialysis was transferred to peritoneal dialysis due to severe cardiac dysfunction. He was treated with mechanical ventilation under sedation with midazolam. However, even though stopping midazolam, deep sedation by midazolam was not restored. The patient completely recovered from sedation after 280 hours.
KEYWORD
Midazolam, Deep sedation, Kidney failure, chronic, Peritoneal dialysis
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